Charged with the development of an ANABOLIC AGENT capable of mimicking the incredible potency and laser precision defining results of the legendary cutting steroid Winstrol, our premiere scientists have done it again!  SteroidAlternatives.com’s WIN-ALT is a remarkable scientifically engineered formula that’s designed to cut you to ribbons.  Its uniquely complex proprietary blend of ingredients represents the very latest in technological synergy and advanced muscular definition. 

At SteroidAlternatives.com, we realize product integrity is no longer a given, but we’re confident in the quality of our ANABOLIC AGENTS and have always contended that an informed consumer is our best customer.  The following material represents our challenge to you.  Below you’ll find this product’s primary ingredients, their respective properties, how they work to build you a better body, and authentic EXCERPTS from prestigious medical journals which include the study aims/purposes and conclusions.  To view the entire clinical abstract, please click the provided hyperlink beneath each excerpt.  Thank you for investigating SteroidAlternatives.com and for the opportunity to prove our value!  
 

WIN-ALT INGREDIENTS 

Vanadyl Sulfate (Vanadium) 

Vanadyl Sulfate is the most popular and common form of vanadium, an element in the body that is found in foods such as pepper, dill, radishes, eggs, vegetable oils, buckwheat, and oats.   

To properly comprehend the importance of Vandayl Sulfate, you must first understand the role and the rationale behind wanting to artificially increase insulin.  Sugar metabolism is the process by which the body converts food into energy that can be used by muscle cells.  This process begins when enzymes break food down into glucose, a simple six carbon sugar that can be easily absorbed in the intestines where it is crucial in the delivery of energy to cells for survival and functioning.  In the body, glucose is the standard form of energy after digestion.  Unfortunately, glucose's size and structure make it hard for the molecule to pass through the outer membranes of many of the body's cells.  Insulin bonds with the outer membrane of cells to increase their permeability.  This enables glucose to pass through the cell membrane more easily and gives the cell access to more energy.  Without insulin, it is extremely difficult for glucose in the blood to be used by the body's cells as energy.  Conversely, an abundance of insulin increases the rate at which it is used by the cells and subsequently lowers the amount of glucose left in the bloodstream.  

In addition to helping to provide cells with energy, insulin also helps cells in other ways.  When insulin increases the permeability of the cell membrane, amino acids also enter the cell.  These amino acids are used to build and repair cell parts and are specifically helpful in enhancing muscle cell growth.  

General Uses:

The physiological role of vanadyl in humans is that of a cofactor, in that it possesses insulin-mimicking activities which support the body when actual insulin is in short supply or unavailable.  This trace element is very important for normal growth and development.  Specifically, it works by altering the concentration and effectiveness of several enzymes that are involved in the breakdown and distribution of glucose molecules and amino acids. 

Anabolic Benefits:

To the body builder, such a substance would be crucial, as more insulin in the body would provide more energy for workouts, more rapid muscle repair, and greater strength gains.   

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“To investigate the efficacy and mechanism of action of vanadium salts as oral hypoglycemic agents, 16 type 2 diabetic patients were studied before and after 6 weeks of vanadyl sulfate (VOSO4) treatment at three doses…Vanadyl sulfate appears safe at these doses for 6 weeks, but at the tolerated doses, it does not dramatically improve insulin sensitivity or glycemic control. Vanadyl modifies proteins in human skeletal muscle involved in early insulin signaling, including basal insulin receptor and substrate tyrosine phosphorylation and activation of PI 3-kinase, and is not additive or synergistic with insulin at these steps...”

Metabolic effects of vanadyl sulfate in humans with non-insulin-dependent diabetes mellitus: in vivo and in vitro studies.” 

Goldfine AB, Patti ME, Zuberi L, Goldstein BJ, LeBlanc R, Landaker EJ, Jiang ZY, Willsky GR, Kahn CR.

Metabolism. 2000 Mar;49(3):400-10.

http://www.ncbi.nlm.nih.gov/pubmed/10726921 

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“BACKGROUND/AIM: Impaired glucose tolerance (IGT) is considered a risk factor for developing type 2 diabetes mellitus (T2DM) and is associated with insulin resistance. Vanadium seems to block protein tyrosine phosphatase with the consequent increment in insulin sensitivity (INS) in T2DM patients, but this effect has not been studied in IGT patients. The aim of this study was to evaluate the effect of vanadium on INS in IGT patients…CONCLUSIONS: VS administration in IGT patients increased triglyceride concentrations without changes in INS.” 

Effect of vanadium on insulin sensitivity in patients with impaired glucose tolerance.

Jacques-Camarena O, González-Ortiz M, Martínez-Abundis E, López-Madrueño JF, Medina-Santillán R.

Ann Nutr Metab. 2008;53(3-4):195-8. Epub 2008 Nov 22.

http://www.ncbi.nlm.nih.gov/pubmed/19033682

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“BACKGROUND: Vanadyl sulfate (VS) and taurine are two promising agents in the treatment of diabetes related to their antihyperglycemic, antihyperlipidemic, and hyperinsulinemic effects…CONCLUSIONS: The findings of the present study suggest that VS and taurine exert beneficial effects on the blood glucose and lipid levels in STZ-NA diabetic rats. However, VS might exert prooxidative or antioxidative effects in various components of the body and taurine and VS combination might be an alternative for sole VS administration.” 

Vanadyl sulfate, taurine, and combined vanadyl sulfate and taurine treatments in diabetic rats: effects on the oxidative and antioxidative systems.

Tas S, Sarandol E, Ayvalik SZ, Serdar Z, Dirican M.

Arch Med Res. 2007 Apr;38(3):276-83. Epub 2007 Jan 22.

http://www.ncbi.nlm.nih.gov/pubmed/17350476 

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“High fructose feeding induces insulin resistance, impaired glucose tolerance, and hypertension in rats and mimics most of the features of the metabolic syndrome X. The effects of a 6-week treatment with the transition metals administered in drinking water, vanadium (VOSO4.5H2O, 0.75 mg/mL) or tungsten (Na2O4W, 2 g/mL), were investigated on the reactivity to norepinephrine (NEPI) or acetylcholine (ACh) of thoracic aorta rings isolated from fructose (60%) or standard chow fed rats…Vanadium, but not tungsten, increased the relaxing activity of ACh, both in control and fructose-fed animals. Insulin resistance associated with high fructose feeding was reversed by vanadium but not by tungsten treatment. The differential effects of the two transition metals on vascular responsiveness to NEPI or ACh may be explained by their differential effects on insulin sensitivity.” 

Differential effects of sodium tungstate and vanadyl sulfate on vascular responsiveness to vasoactive agents and insulin sensitivity in fructose-fed rats.

Al-Awwadi N, Bichon-Laurent F, Dimo T, Michel A, Portet K, Cros G, Poucheret P.

Can J Physiol Pharmacol. 2004 Oct;82(10):911-8.

http://www.ncbi.nlm.nih.gov/pubmed/15573152 

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“Nitric oxide (NO) has been shown to act as a mediator of cytokines in bone tissue. We have previously demonstrated that vanadium compounds are insulin- and growth factor-mimetic compounds in osteoblasts in culture, although high doses are toxic to these cells…Experiments performed with the ionophore A23187 and EGTA suggested that vanadate-induced NO production involves Ca(2+)-dependent and -independent mechanisms. Altogether, our results suggest that NO may play a critical role in the bioactivity of vanadium in osteoblast-like cells.” 

Vanadate-induced nitric oxide production: role in osteoblast growth and differentiation.

Cortizo AM, Caporossi M, Lettieri G, Etcheverry SB.

Eur J Pharmacol. 2000 Jul 21;400(2-3):279-85.

http://www.ncbi.nlm.nih.gov/pubmed/10988345 

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“Occupational exposure by inhalation to vanadium-containing particles such as residual oil fly ash results in respiratory tract inflammation. This inflammation, characterized by abundant neutrophilia, appears to be initiated by alveolar macrophages (AMs) encountering particles and the subsequent release of proinflammatory cytokines…These observations demonstrate that in vitro metavanadate exposure regulates two distinct, yet related intracellular signaling pathways important in initiating inflammatory responses in these cells: (1) activation of the NADPH oxidase complex with subsequent increased ROI synthesis, and (2) enhanced tyrosine phosphorylation of cellular proteins.” 

Mediating phosphorylation events in the vanadium-induced respiratory burst of alveolar macrophages.

Grabowski GM, Paulauskis JD, Godleski JJ.

Toxicol Appl Pharmacol. 1999 May 1;156(3):170-8.

http://www.ncbi.nlm.nih.gov/pubmed/10222309 

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“Diabetes mellitus is accompanied by hormonal and neurochemical changes that can be associated with anxiety and depression. Both diabetes and depression negatively interact, in that depression leads to poor metabolic control and hyperglycemia exacerbates depression. We hypothesize one novel vanadium complex of vanadium-enriched Cordyceps sinensis (VECS), which is beneficial in preventing depression in diabetes, and influences the long-term course of glycemic control. Vanadium compounds have the ability to imitate the action of insulin, and this mimicry may have further favorable effects on the level of treatment satisfaction and mood. C. sinensis has an antidepressant-like activity, and attenuates the diabetes-induced increase in blood glucose concentrations. We suggest that the VECS may be a potential strategy for contemporary treatment of depression and diabetes through the co-effect of C. sinensis and vanadium. The validity of the hypothesis can most simply be tested by examining blood glucose levels, and swimming and climbing behavior in streptozotocin-induced hyperglycemic rats.” 

A Contemporary Treatment Approach to Both Diabetes and Depression by Cordyceps sinensis, Rich in Vanadium.

Guo JY, Han CC, Liu YM.

Evid Based Complement Alternat Med. 2009 Nov 30.

http://www.ncbi.nlm.nih.gov/pubmed/19948751 

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Dandelion

GENERAL USES:

Dandelion, also know as Taraxacum Officinale, has been a staple of the traditional herbal pharmacopeia for centuries.  In Europe, the dandelion is highly respected as the nutritional and medicinal powerhouse.  

Among other things, dandelion root and other plants of the dandelion have been used as a mild laxative and potent diuretic combination, a digestive aid, a treatment for liver and kidney problems, inflammation relief, boils, fever and diarrhea.  Dandelion root is known to stimulate the appetite and as a substantial anti-oxidant.  In Europe dandelion greens are often added to salads and used in the same way as lettuce and other greens, and is believed to help regulate blood sugar levels. 

ANABOLIC BENEFITS:

“Flavonoids and coumaric acid derivatives were identified from dandelion flower (Taraxacum officinale). Characteristics of chain-breaking antioxidants, such as extended lag phase and reduced propagation rate, were observed in oxidation of linoleic acid emulsion with the addition of dandelion flower extract (DFE). DFE suppressed both superoxide and hydroxyl radical, while the latter was further distinguished by both site-specific and non-specific hydroxyl radical inhibition…These results showed that the DFE possessed marked antioxidant activity in both biological and chemical models. Furthermore, the efficacy of DFE in inhibiting both reactive oxygen species and nitric oxide were attributed to its phenolic content.” 

Dandelion (Taraxacum officinale) flower extract suppresses both reactive oxygen species and nitric oxide and prevents lipid oxidation in vitro.

Hu C, Kitts DD.

Phytomedicine. 2005 Aug;12(8):588-97.

http://www.ncbi.nlm.nih.gov/pubmed/16121519 

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“Latex of dandelion roots contains a serine proteinase that hydrolyzes a chromogenic peptide substrate Glp-Ala-Ala-Leu-pNA optimally at pH 8.0…Pure serine proteinase named taraxalisin was inactivated by specific inhibitors of serine proteinases, diisopropylfluorophosphate (DFP) and phenylmethylsulfonylfluoride (PMSF). The substrate specificity of taraxalisin towards synthetic peptides and insulin B-chain is comparable with that of two other subtilisin-like serine proteinases, cucumisin and macluralisin. The taraxalisin N-terminal sequence traced for 15 residues revealed 40% coinciding residues when aligned with that of subtilisin Carlsberg.” 

Taraxalisin -- a serine proteinase from dandelion Taraxacum officinale Webb s.l.

Rudenskaya GN, Bogacheva AM, Preusser A, Kuznetsova AV, Dunaevsky YaE, Golovkin BN, Stepanov VM.

FEBS Lett. 1998 Oct 23;437(3):237-40.

http://www.ncbi.nlm.nih.gov/pubmed/9824298 

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“Nitric oxide (NO) produced at high concentrations by the inducible NO synthase is an important effector molecule involved in immune regulation and defense. The involvement of NO in the toxicity of cadmium (Cd) has been proposed. In the present study, we searched restoration drug against the inhibition of NO production by Cd in Oriental medicine. An aqueous extract of Taraxacum officinale (Compositae) (TOAE) restored the inhibition of NO production by mouse peritoneal macrophages pretreated with Cd in a dose-dependent manner. The effect of TOAE was mainly dependent on TOAE-induced tumor necrosis factor-alpha (TNF-alpha) secretion. These results suggest that the capacity of TOAE to restore NO production from interferon-gamma (IFN-gamma)-primed mouse peritoneal macrophages is the result of TOAE-induced TNF-alpha secretion.” 

Taraxacum officinale restores inhibition of nitric oxide production by cadmium in mouse peritoneal macrophages.

Kim HM, Lee EH, Shin TY, Lee KN, Lee JS.

Immunopharmacol Immunotoxicol. 1998 May;20(2):283-97.

http://www.ncbi.nlm.nih.gov/pubmed/9653673 

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“To investigate the efficacy and the mechanism of the anti-inflammatory effect of Taraxacum officinale leaves (TOLs), the effect of a methanol extract and its fractions recovered from TOLs on lipopolysaccharide (LPS)-induced responses was studied in the mouse macrophage cell line, RAW 264.7…These results show that the anti-inflammatory effects of TOLs are probably due to down-regulation of NO, PGE(2), and pro-inflammatory cytokines and reduced expressions of iNOS and COX-2 via inactivation of the MAP kinase signal pathway.” 

Anti-Inflammatory Effect of Taraxacum officinale Leaves on Lipopolysaccharide-Induced Inflammatory Responses in RAW 264.7 Cells.

Koh YJ, Cha DS, Ko JS, Park HJ, Choi HD.

J Med Food. 2010 Aug;13(4):870-8.

http://www.ncbi.nlm.nih.gov/pubmed/20673058 

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Caffeine  

Caffeine is a central nervous system stimulant most often found in coffee beans and tea leaves.  Clinical studies have shown its effects to extremely diverse and apparently contingent upon the uses for which it is employed making it an excellent facilitator/ancillary ingredient that literally amplifies the properties of other products. 

General Uses:

Caffeine is primarily used to stimulate metabolic rate and, in so doing, promote alertness, reduce drowsiness and improve coordination.  It has been found to increase energy expenditure and thereby enhance weight loss and fat loss activities.  Recent clinical data has demonstrated that caffeine in conjunction with routine anabolic training can actually increase strength levels in the user (see below). 

Anabolic Benefits:

“…Therefore, the purpose of this study was to determine the acute effects of caffeine supplementation on strength and muscular endurance in resistance-trained women…RESULTS: Repeated measures ANOVA indicated a significantly greater bench press maximum with caffeine (p </= 0.05) (52.9 +/- 11.1 kg vs. 52.1 +/- 11.7 kg) with no significant differences between conditions in 60% 1RM repetitions (p = 0.81). Systolic blood pressure was significantly greater post-exercise, with caffeine (p < 0.05) (116.8 +/- 5.3 mmHg vs. 112.9 +/- 4.9 mmHg). CONCLUSIONS: These findings indicate a moderate dose of caffeine may be sufficient for enhancing strength performance in resistance-trained women.” 

Caffeine enhances upper body strength in resistance-trained women.

Goldstein E, Jacobs PL, Whitehurst M, Penhollow T, Antonio J.

J Int Soc Sports Nutr. 2010 May 14;7:18.

http://www.ncbi.nlm.nih.gov/pubmed/20470411 

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“A series of four trials was carried out to investigate the effects of caffeine and coffee on the metabolic rate and substrate utilization in normal weight and obese individuals…In conclusion caffeine/coffee stimulates the metabolic rate in both control and obese individuals; however, this is accompanied by greater oxidation of fat in normal weight subjects.” 

Caffeine and coffee: their influence on metabolic rate and substrate utilization in normal weight and obese individuals.

KJ Acheson, B Zahorska-Markiewicz, P Pittet, K Anantharaman and E Jequier (1980)

American Journal of Clinical Nutrition, Vol 33, 989-997

http://www.ajcn.org/cgi/content/abstract/33/5/989?maxtoshow=&hits=10&RESULTFORMAT=&fulltext=caffeine+fat+loss&searchid=1&FIRSTINDEX=10&resourcetype=HWCIT 

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“Single-dose oral administration of 100 mg caffeine increased the resting metabolic rate of both lean and postobese human volunteers by 3-4%…The net effect was a significant increase (p less than 0.02) in daily energy expenditure of 150 kcal in the lean volunteers and 79 kcal in the postobese subjects. Caffeine at commonly consumed doses can have a significant influence on energy balance and may promote thermogenesis the treatment of obesity.”  

Normal caffeine consumption: influence on thermogenesis and daily energy expenditure in lean and post-obese human volunteers.

Dulloo, A. G., Geissler, C. A., Horton, T., Collins, A. and Miller, D. S. (1989)

American Journal of Clinical Nutrition. 49, 44-50.  

http://www.ajcn.org/cgi/content/abstract/49/1/44?maxtoshow=&hits=10&RESULTFORMAT=&fulltext=Normal+caffeine+consumption:+influence+on+thermogenesis+and+daily+energy+expenditure+in+lean+and+post-obese+human+volunteers.&searchid=1&FIRSTINDEX=0&resourcetype=HWCIT